Asian Journal of Research in Medicine and Medical Science

A chronic, recurrent, and remitting vasculitis with an unclear cause is Behçet's disease (BD). Because it can affect veins and arteries of all diameters, it can impact nearly every organ system and cause serious organ-threatening disease and mortality. Known historically as the "Silk Road" disease, it is a condition that occurs worldwide. Although genome-wide investigations reveal connections between human leukocyte antigens and non-human leukocyte antigens, the neuropathological processes underlying disease development in BD are still poorly understood. The autoimmune and auto-inflammatory nature of BD is suggested by the possibility that both hereditary and environmental factors contribute to the aetiopathogenetic pathways that cause the disease to develop. There is little evidence to support treatment, although new information is being discovered, and available therapies encompass a wide range of clinical presentations, from symptomatic care to biological and non-biological immunosuppressive medications.